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结直肠癌肝转移综合治疗指南-Colorectal Cancer Liver Metastases: A Comprehensive Guide to Management

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标题(title):Colorectal Cancer Liver Metastases: A Comprehensive Guide to Management
结直肠癌肝转移综合治疗指南
作者(author):Mauro Monteiro Correia, Michael A. Choti, Flavio G. Rocha, Go Wakabayashi
出版社(publisher):Springer International Publishing
大小(size):14 MB (14934879 bytes)
格式(extension):pdf
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Colorectal cancer is the third most commonly diagnosed condition in oncology, affecting around 1.23 million individuals per year, according to recent statistics. Of these patients, about 50% will develop liver metastases and approximately 20% will present a stage IV disease at diagnosis. These statistics make colorectal liver metastases (CLM) an issue of major importance in current oncology.

The area of CLM is subject to great and continuous advances, as its pathophysiologic mechanisms are better understood and more therapeutic and surgical options are developed. Consequently, all professionals involved with the diagnosis, treatment and follow up of CLM should be kept up to date with the latest advances on the field, to provide high standard medical care to their patients.



This book is designed to present the state-of-the-art in CLM management and, in doing so, to review the current evidence on CLM, discussing all important topics in the field. Coverage is broad and comprehensive, encompassing introductory topics (history, definitions, epidemiology, etc.), basic science subjects (molecular biology, genetics, dissemination process, etc.) and practical clinical topics (tumor behavior, diagnosis, drug therapy, radiation therapy, surgery, ablation, multidisciplinary teams, etc.).

Although comprehensive on the coverage and selection of topics, each chapter is concise and objective, dissecting topics in a practical and direct format. Evidences and recommendations are included. Chapters display a brief introduction of the common knowledge, go straight to the detailed revision of the most recent years of the literature, and end with practical closing observations.



This book is a tool for professionals (general and cancer surgeons, HPB surgeons, clinical oncologists, gastroenterologists and medical residents) and interns who search for a qualified and reader friendly revision on topics concerning Colorectal Cancer Liver Metastases.



Table of contents :
Front Matter ....Pages i-xvii
Surgical Treatment of Colorectal Cancer Liver Metastases (CRLM) - Historical Aspects (Carlos Eduardo Rodrigues Santos, Mauro Monteiro Correia)....Pages 1-6
The Biology of Colorectal Liver Metastases (Mathew M. Augustine)....Pages 7-20
Molecular Biomarkers for the Management of Colorectal Cancer Liver Metastases (Malcolm H. Squires III, Jordan M. Cloyd, Timothy M. Pawlik)....Pages 21-34
Diagnosis of Colorectal Liver Metastases (Roberto Heleno Lopes, Bruno Roberto Braga Azevedo, André Noronha Arvellos, Phillipe Abreu-Reis, Alexandre Ferreira Oliveira)....Pages 35-48
Role of Imaging in the Management of Patients with Potentially Resectable CRLM (Khalid W. Shaqdan, Ali Pourvaziri, Dushyant V. Sahani)....Pages 49-64
Staging Classifications of Colorectal Liver Metastases (Toru Beppu, Go Wakabayashi, Katsunori Imai, Yasushi Yoshida, Hideo Baba)....Pages 65-85
Prognostic Factors of Colorectal Cancer Liver Metastasis (Felipe José Fernández Coimbra, Paulo Henrique Miranda Brandão, Alessandro Landskron Diniz, Heber Salvador de Castro Ribeiro, Wilson Luiz da Costa Júnior, André Luiz de Godoy et al.)....Pages 87-94
Clinical Scoring Systems for Colorectal Cancer Liver Metastases (Camille Stewart, Yuman Fong)....Pages 95-111
What Is the Impact of Positive Margins in the Liver? (Ibrahim Nassour, Michael A. Choti)....Pages 113-117
Multidisciplinary Team (MDT) and the Management of Colorectal Cancer Liver Metastases (Mauro Monteiro Correia)....Pages 119-127
Defining Resectability of Colorectal Cancer Liver Metastases: Technical and Oncologic Perspectives (Rebecca K. Marcus, Thomas A. Aloia)....Pages 129-144
Algorithms for Patients with Colorectal Liver Metastasis (Orlando Jorge Martins Torres, Marcos Belotto de Oliveira, Paulo Cezar Galvão do Amaral, Eliza Dalsasso Ricardo, Agnaldo Soares Lima, Alexandre Prado de Resende et al.)....Pages 145-157
Treatment Options for Resectable Colorectal Liver Metastases in the Presence of Extrahepatic Disease (Kimberly A. Bertens, Jad Abou Khalil, Guillaume Martel)....Pages 159-172
Anatomical, Physiological, and Kinetic Evaluation of the Future Liver Remnant of CRLM After Portal Vein Embolisation (D. Asano, D. Ban, M. Tanabe)....Pages 173-183
Systemic Therapy for Colorectal Cancer Liver Metastases: Sorting Through the Options (Bhavana P. Singh, Benjamin A. Weinberg, Sunnie S. Kim, John L. Marshall)....Pages 185-203
Neoadjuvant Chemotherapy for Resectable Colorectal Cancer Liver Metastases: Indications and Results (Anna Ryan, John Bridgewater)....Pages 205-228
Management of Disappearing Liver Metastasis Following Preoperative Chemotherapy (Georgios Karagkounis, Michael A. Choti)....Pages 229-238
Conversion Chemotherapy for CRLM-Best Associations, and Does Conversion Translate into Longer Survival? (Mariana Bruno Siqueira, João Paulo Fogacci, Roberto de Almeida Gil, Mauro Monteiro Correia)....Pages 239-247
Adjuvant Chemotherapy for CRLM: Indications and Results (Carlos José Coelho de Andrade)....Pages 249-258
Surgical Outcome of Colorectal Cancer Liver Metastases in Our Facility: Efficacy of Conversion Surgery in Initially Unresectable Colorectal Liver Metastases (Shigeyuki Kawachi, Naokazu Chiba, Koichi Tomita, Toru Sano, Motohide Shimazu)....Pages 259-267
Immunotherapy in the Management of Colorectal Cancer Liver Metastasis (Thuy B. Tran, Ajay V. Maker)....Pages 269-282
Adjuvant Hepatic Arterial Infusion Therapy (Vitor Moutinho, Louise C. Connell, Nancy Kemeny)....Pages 283-296
Sequencing of Systemic Chemotherapy for Unresectable CRLM (Marc T. Roth, Laura W. Goff)....Pages 297-312
Role of Hepatic Artery Infusion Pump Chemotherapy for Unresectable Colorectal Cancer Liver Metastases (Jashodeep Datta, Michael I. D’Angelica)....Pages 313-327
Enhanced Recovery After Liver Surgery (Eve Simoneau, Thomas A. Aloia, Ching-Wei D. Tzeng)....Pages 329-343
Surgical Results for Synchronous Colorectal Cancer Liver Metastases (Rinaldo Gonçalves, Marcus Valadão, Rodrigo Araújo)....Pages 345-354
Resection of Metachronous Colorectal Cancer Liver Metastases: Surgical Outcomes (Fábio Luiz Waechter, Uirá Fernandes Teixeira, Pablo Duarte Rodrigues, Marcio Boff, Rinaldo Danesi, Mauro Monteiro Correia)....Pages 355-369
Laparoscopic Resections for Colorectal Cancer Liver Metastases (Giammauro Berardi, Go Wakabayashi)....Pages 371-384
Robotic Partial Hepatectomy for Colorectal Cancer Liver Metastases (Eric C. H. Lai, Chung Ngai Tang)....Pages 385-395
Navigation and Augmented Reality for Liver Surgery (Mauro Monteiro Correia)....Pages 397-411
Staged Hepatectomies for Colorectal Cancer Liver Metastases: When and How (Georgios Antonios Margonis, Matthew J. Weiss)....Pages 413-428
Parenchymal-Sparing Surgery: What Is Behind It? (Adriana C. Gamboa, Shishir K. Maithel)....Pages 429-444
Resection of the Primary in Unresectable Colorectal Cancer Liver Metastases – Is It Worth? (Marcus Valadão, Rinaldo Gonçalves, Rodrigo Araújo, Roberto de Almeida Gil)....Pages 445-453
Liver Pedicle Lymphadenectomy: How and When? (Jaime A. P. Krüger, Paulo Herman)....Pages 455-468
ALPPS for Colorectal Cancer Liver Metastases—Short and Long-Term Results (Kerollos Nashat Wanis, Bao Tram Nghiem, Roberto Hernandez-Alejandro)....Pages 469-486
Ablative Techniques for CRLM: Alone or in Association (Mariana I. Chavez, Christopher Coon, T. Clark Gamblin)....Pages 487-506
Chemoembolization for Colorectal Liver Metastases (José Hugo Mendes Luz)....Pages 507-518
Role of Y90 Radioembolization in Hepatic Metastatic Colorectal Carcinoma (Rehan Ali, Ahmed Gabr, Ronald Mora, Ahsun Riaz, Robert Lewandowski)....Pages 519-529
Liver Transplantation for CRLM—Is It Ever Indicated? (Pål-Dag Line, Morten Hagness, Svein Dueland)....Pages 531-546
External Radiation for Unresectable CRLM (Raquel Guimarães Domingos da Silva, M. Carmen Rubio Rodriguez)....Pages 547-560
Lessons from Collaborative Big Data—Insights from LiverMetSurvey Registry (Marc-Antoine Allard, René Adam)....Pages 561-569
Prognosis and Management of Recurrent Metastatic Colorectal Cancer (Blaire Anderson, Ryan C. Fields)....Pages 571-587
Back Matter ....Pages 589-598
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