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癌症中的果蝇模型-The Drosophila Model in Cancer

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标题(title):The Drosophila Model in Cancer
癌症中的果蝇模型
作者(author):Wu-Min Deng
出版社(publisher):Springer International Publishing
大小(size):10 MB (10216778 bytes)
格式(extension):pdf
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This volume provides a series of review articles that capture the advances in using the fruit fly, Drosophila melanogaster, model system to address a wide range of cancer-related topics. Articles in this book provide case studies that shed light on the intricate cellular and molecular mechanisms underlying tumor formation and progression.


Readers will discover the beauty of the fly model’s genetic simplicity and the vast arsenal of powerful genetic tools enabling its efficient and adaptable use. This model organism has provided a unique opportunity to address questions regarding cancer initiation and development that would be extremely challenging in other model systems.



This book provides a useful resource for a researcher who wishes to learn about and apply the Drosophila model to tackle fundamental questions in cancer biology, and to find new ways to fight against this devastating disease.


Table of contents :
Front Matter ....Pages i-vi
Drosophila Model in Cancer: An Introduction (Deeptiman Chatterjee, Wu-Min Deng)....Pages 1-14
Using Drosophila Models and Tools to Understand the Mechanisms of Novel Human Cancer Driver Gene Function (Santiago Nahuel Villegas, Dolors Ferres-Marco, María Domínguez)....Pages 15-35
Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis (Natasha Fahey-Lozano, John E. La Marca, Marta Portela, Helena E. Richardson)....Pages 37-64
Two Sides of the Same Coin – Compensatory Proliferation in Regeneration and Cancer (Neha Diwanji, Andreas Bergmann)....Pages 65-85
The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues (Yoichiro Tamori)....Pages 87-103
P53 and Apoptosis in the Drosophila Model (Lei Zhou)....Pages 105-112
Autophagy and Tumorigenesis in Drosophila (Royjar Khezri, Tor Erik Rusten)....Pages 113-127
Understanding Obesity as a Risk Factor for Uterine Tumors Using Drosophila (Xiao Li, Mengmeng Liu, Jun-Yuan Ji)....Pages 129-155
MicroRNAs in Drosophila Cancer Models (Moritz Sander, Héctor Herranz)....Pages 157-173
Cancer Stem Cells and Stem Cell Tumors in Drosophila (Shree Ram Singh, Poonam Aggarwal, Steven X. Hou)....Pages 175-190
Drosophila as a Model for Tumor-Induced Organ Wasting (Pedro Saavedra, Norbert Perrimon)....Pages 191-205
Drosophila melanogaster as a Model System for Human Glioblastomas (Alexander S. Chen, Renee D. Read)....Pages 207-224
What Drosophila Can Teach Us About Radiation Biology of Human Cancers (Tin Tin Su)....Pages 225-236
A Drosophila Based Cancer Drug Discovery Framework (Erdem Bangi)....Pages 237-248
Back Matter ....Pages 249-250
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