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肝细胞癌:平移精确医学途径-Hepatocellular Carcinoma: Translational Precision Medicine Approaches

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上传于 2020-03-02 0次下载 5297次围观
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标题(title):Hepatocellular Carcinoma: Translational Precision Medicine Approaches
肝细胞癌:平移精确医学途径
作者(author):Yujin Hoshida
出版社(publisher):Springer International Publishing;Humana
大小(size):8 MB (8782264 bytes)
格式(extension):pdf
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This book provides a comprehensive overview of the current limitations and unmet needs in Hepatocellular Carcinoma (HCC) diagnosis, treatment, and prevention. It also provides newly emerging concepts, approaches, and technologies to address challenges. Topics covered include changing landscape of HCC etiologies in association with health disparities, framework of clinical management algorithm, new and experimental modalities of HCC diagnosis and prognostication, multidisciplinary treatment options including rapidly evolving molecular targeted therapies and immune therapies, multi-omics molecular characterization, and clinically relevant experimental models. The book is intended to assist collaboration between the diverse disciplines and facilitate forward and reverse translation between basic and clinical research by providing a comprehensive overview of relevant areas, covering epidemiological trend and population-level patient management strategies, new diagnostic and prognostic tools, recent advances in the standard care and novel therapeutic approaches, and new concepts in pathogenesis and experimental approaches and tools, by experts and opinion leaders in their respective fields.

By thoroughly and concisely covering whole aspects of HCC care, Hepatocellular Carcinoma serves as a valuable reference for multidisciplinary readers, and promotes the development of personalized precision care strategies that lead to substantial improvement of disease burden and patient prognosis in HCC.


Table of contents :
Front Matter ....Pages i-xv
Front Matter ....Pages 1-1
Risk Factors of Hepatocellular Carcinoma for Precision Personalized Care (Naoto Fujiwara, Po-Hong Liu, Sai Krishna Athuluri-Divakar, Shijia Zhu, Yujin Hoshida)....Pages 3-25
Hepatocellular Carcinoma Surveillance and Staging (Amit G. Singal, Neehar D. Parikh, Nicole E. Rich, Binu V. John, Anjana Pillai)....Pages 27-51
Changing Epidemiology of Hepatocellular Carcinoma and Role of Surveillance (Yueran Zhuo, Qiushi Chen, Jagpreet Chhatwal)....Pages 53-67
Front Matter ....Pages 69-69
Radiological Diagnosis and Characterization of HCC (Naik Vietti Violi, Sara Lewis, Stefanie Hectors, Daniela Said, Bachir Taouli)....Pages 71-92
Analysis of Hepatocellular Carcinoma Tissue for Biomarker Discovery (Connor A. West, Alyson P. Black, Anand S. Mehta)....Pages 93-107
Molecular Subtypes and Genomic Signatures of Hepatocellular Carcinoma for Prognostication and Therapeutic Decision-Making (Sung Hwan Lee, Sun Young Yim, Jae-Jun Shim, Ju-Seog Lee)....Pages 109-123
Liquid Biopsy in Hepatocellular Carcinoma (Irun Bhan, Daniel A. Haber, Raymond T. Chung, David T. Ting)....Pages 125-141
Front Matter ....Pages 143-143
Surgical Therapies in Hepatocellular Carcinoma (Caitlin A. Hester, Adam C. Yopp)....Pages 145-167
Interventional Radiologic Therapies for Hepatocellular Carcinoma: From Where We Began to Where We Are Going (Patrick D. Sutphin, Daniel Lamus, Sanjeeva P. Kalva, Junjie Li, Ian R. Corbin)....Pages 169-194
Precision Locoregional Therapies for Hepatocellular Carcinoma: Percutaneous Ablation and Radiotherapy (Ryosuke Tateishi, Naoto Fujiwara)....Pages 195-224
Molecular-Targeted Therapies in Hepatocellular Carcinoma (Amit Mahipal, Anuhya Kommalapati, Rutika Mehta, Richard D. Kim)....Pages 225-238
Immune Therapies (Zachary J. Brown, Tim F. Greten)....Pages 239-253
Prevention Strategies for Hepatocellular Carcinoma (Derek J. Erstad, Allen A. Razavi, Shen Li, Kenneth K. Tanabe, Bryan C. Fuchs)....Pages 255-289
Front Matter ....Pages 291-291
Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma (Man Hsin Hung, Xin Wei Wang)....Pages 293-316
Stromal and Immune Drivers of Hepatocarcinogenesis (Antonio Saviano, Natascha Roehlen, Alessia Virzì, Armando Andres Roca Suarez, Yujin Hoshida, Joachim Lupberger et al.)....Pages 317-331
Experimental Models for Preclinical Research in Hepatocellular Carcinoma (Pedro Molina-Sánchez, Amaia Lujambio)....Pages 333-358
Back Matter ....Pages 359-364
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