标题（title）：Hydrogenosomes and Mitosomes: Mitochondria of Anaerobic Eukaryotes
出版社（publisher）：Springer International Publishing
大小（size）：10 MB (10510710 bytes)
The new edition focuses on the latest information on mitochondrion-derived organelles, particularly on hydrogenosomes and mitosomes. It has become more and more evident that hydrogenosomes and mitosomes are just two specific members of larger family of organelles derived to various extent from mitochondria due to adaptation to oxygen-poor environment and to the parasitic life style. Since the 1st edition, investigation of free-living protists and commensals has revealed that there is a continuous spectrum of mitochondria-derived organelles from typical aerobic mitochondria, mitochondria with stepwise loss of respiratory chain complexes and with concomitant gain of anaerobic pathways (particularly hydrogenase), via hydrogenosomes and mitosomes to the newly discovered organisms that completely lost mitochondria.
Most of the experimental data collected relates to the human pathogens Trichomonas vaginalis harboring hydrogenosomes, and Giardia intestinalis and Entamoeba histolytica with mitosoms. In principle, hydrogenosomes are hydrogen and ATP producing organelles, while the only known function in Giardia mitosomes is synthesis of iron-sulfur clusters, whereas mitosomes of E. histolytica possess the recently discovered sulfur activation pathway. Functions of other unusual mitochondria are mostly predicted based on transcriptomic/genomic analyses as corresponding organisms are not amenable to biochemical studies.
Investigations on evolution and function of mitochondria-derived organelles substantially changed conventional views on mitochondrion from textbook models of an oxygen-consuming powerhouse of cells to a large family of organelles, variables in their structure and function in which hydrogenosomes and mitosome represent the most divergent anaerobic members.
Table of contents :
Front Matter ....Pages i-viii
The Hydrogenosome Is Born: In Memoriam Donald G. Lindmark (Miklós Müller)....Pages 1-5
The Evolution of Oxygen-Independent Energy Metabolism in Eukaryotes with Hydrogenosomes and Mitosomes (Verena Zimorski, William F. Martin)....Pages 7-29
Protein Import into Hydrogenosomes and Mitosomes (Pavel Dolezal, Abhijith Makki, Sabrina D. Dyall)....Pages 31-84
Structure of the Hydrogenosome (Marlene Benchimol, Wanderley de Souza)....Pages 85-110
Hydrogenosomes of Anaerobic Ciliates (Johannes H. P. Hackstein, Rob M. de Graaf, Jaap J. van Hellemond, Aloysius G. M. Tielens)....Pages 111-126
Metabolism of Trichomonad Hydrogenosomes (Ivan Hrdý, Jan Tachezy, Miklós Müller)....Pages 127-158
Hydrogenosomes of Anaerobic Fungi: An Alternative Way to Adapt to Anaerobic Environments (Johannes H. P. Hackstein, Scott E. Baker, Jaap J. van Hellemond, Aloysius G. M. Tielens)....Pages 159-175
The Proteome of T. vaginalis Hydrogenosomes (Petr Rada, Jan Tachezy)....Pages 177-204
Mitosomes in Parasitic Protists (Jan Tachezy, Ondřej Šmíd)....Pages 205-242
The Mitochondrion-Related Organelles of Cryptosporidium Species (Anastasios D. Tsaousis, Janet S. Keithly)....Pages 243-266
The Mitochondrion-Related Organelles of Blastocystis (Anastasios D. Tsaousis, Nigel Yarlett, Kevin S. W. Tan)....Pages 267-286
Mitochondrion-Related Organelles in Free-Living Protists (Michelle M. Leger, Martin Kolísko, Courtney W. Stairs, Alastair G. B. Simpson)....Pages 287-308
Organisms Without Mitochondria, How It May Happen? (Vladimír Hampl)....Pages 309-318
Back Matter ....Pages 319-326