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细胞因子风暴综合征-Cytokine Storm Syndrome

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上传于 2020-03-02 52次下载 5583次围观
文件编号:6276
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标题(title):Cytokine Storm Syndrome
细胞因子风暴综合征
作者(author):Randy Q. Cron, Edward M. Behrens
出版社(publisher):Springer International Publishing
大小(size):10 MB (11007985 bytes)
格式(extension):pdf
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Cytokine Storm Syndromes, including HLH and MAS, are frequently fatal disorders, particularly if not recognized early and treated during presentation. The genetics of Cytokine Storm Syndromes are being defined with many of the risk alleles giving rise to mutations in the perforin-mediated cytolytic pathway used by CD8 cytotoxic T cells and natural killer cells. These are being studied using murine models. Up to 10% of the general population may carry risk alleles for developing Cytokine Storm Syndromes, and Cytokine Storm Syndromes are being increasingly recognized around the world in pediatric and adult hospitals.

A variety of infectious, rheumatic, and oncologic triggers are commonly associated with Cytokine Storm Syndromes, but understanding this disorder is critical for all researchers and physicians to ensure timely and appropriate therapy. This textbook, the first of its kind, addresses all aspects of the disorder – from genetics, pathophysiology, and ongoing research, to clinical presentations, risk factors, and treatment.




Table of contents :
Front Matter ....Pages i-xxi
Front Matter ....Pages 1-1
History of Hemophagocytic Lymphohistiocytosis (Gritta E. Janka)....Pages 3-16
The History of Macrophage Activation Syndrome in Autoimmune Diseases (Earl D. Silverman)....Pages 17-29
Clinical Features of Cytokine Storm Syndrome (Masaki Shimizu)....Pages 31-41
Laboratory Features and Pathology of the Cytokine Storm Syndromes (Flavia G. Rosado, Purva Gopal)....Pages 43-59
Criteria for Cytokine Storm Syndromes (Francesca Minoia, Sergio Davì, Alessandra Alongi, Angelo Ravelli)....Pages 61-79
Front Matter ....Pages 81-81
Genetics of Primary Hemophagocytic Lymphohistiocytosis (Spyridon Karageorgos, Hamid Bassiri)....Pages 83-111
Genetics of Acquired Cytokine Storm Syndromes (Grant S. Schulert, Kejian Zhang)....Pages 113-129
Genetics of Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis (Alexei A. Grom)....Pages 131-138
Front Matter ....Pages 139-139
CD8+ T Cell Biology in Cytokine Storm Syndromes (Takuya Sekine, Donatella Galgano, Giovanna P. Casoni, Marie Meeths, Yenan T. Bryceson)....Pages 141-161
Immunology of Cytokine Storm Syndromes: Natural Killer Cells (Anthony R. French, Megan A. Cooper)....Pages 163-181
Myeloid Cells in the Immunopathogenesis of Cytokine Storm Syndromes (Lehn K. Weaver)....Pages 183-195
Cytokines in Cytokine Storm Syndrome (Edward M. Behrens)....Pages 197-207
Primary Immunodeficiencies and Cytokine Storm Syndromes (David A. Hill, Neil Romberg)....Pages 209-232
Front Matter ....Pages 233-233
Infectious Triggers of Cytokine Storm Syndromes: Herpes Virus Family (Non-EBV) (Daniel Dulek, Isaac Thomsen)....Pages 235-252
Cytokine Storm Syndromes Associated with Epstein–Barr Virus (Katherine C. Verbist, Kim E. Nichols)....Pages 253-276
Cytokine Storm Syndrome Associated with Hemorrhagic Fever and Other Viruses (Ethan S. Sen, A. V. Ramanan)....Pages 277-297
Cytokine Storm Syndrome as a Manifestation of Primary HIV Infection (Nathan Erdmann, Sonya L. Heath)....Pages 299-306
Bacteria-Associated Cytokine Storm Syndrome (Esraa M. Eloseily, Randy Q. Cron)....Pages 307-317
Zoonotic Bacterial Infections Triggering Cytokine Storm Syndrome (Zaher K. Otrock, Charles S. Eby)....Pages 319-330
Parasitic and Fungal Triggers (Gary Sterba, Yonit Sterba)....Pages 331-345
Front Matter ....Pages 347-347
Cytokine Storm Syndrome Associated with Systemic Juvenile Idiopathic Arthritis (Rayfel Schneider, Susan P. Canny, Elizabeth D. Mellins)....Pages 349-379
Systemic Lupus Erythematosus and Cytokine Storm (Roberto Caricchio)....Pages 381-392
Kawasaki Disease-Associated Cytokine Storm Syndrome (Rolando Ulloa-Gutierrez, Martin Prince Alphonse, Anita Dhanranjani, Rae S. M. Yeung)....Pages 393-406
The Intersections of Autoinflammation and Cytokine Storm (Scott W. Canna)....Pages 407-421
Macrophage Activation Syndrome in the Setting of Rheumatic Diseases (W. Winn Chatham)....Pages 423-434
Front Matter ....Pages 435-435
Hemophagocytic Lymphohistiocytosis in the Context of Hematological Malignancies and Solid Tumors (Kai Lehmberg)....Pages 437-449
Cytokine Storm and Sepsis-Induced Multiple Organ Dysfunction Syndrome (Joseph A. Carcillo, Bita Shakoory)....Pages 451-464
Front Matter ....Pages 465-465
Murine Models of Familial Cytokine Storm Syndromes (Benjamin Volkmer, Peter Aichele, Jana Pachlopnik Schmid)....Pages 467-489
Murine Models of Secondary Cytokine Storm Syndromes (Ellen Brisse, Carine H. Wouters, Patrick Matthys)....Pages 491-518
Front Matter ....Pages 519-519
Etoposide Therapy of Cytokine Storm Syndromes (Jan-Inge Henter, Tatiana von Bahr Greenwood)....Pages 521-547
IL-1 Family Blockade in Cytokine Storm Syndromes (Randy Q. Cron)....Pages 549-559
IL-6 Blockade in Cytokine Storm Syndromes (David Barrett)....Pages 561-568
Anti-interferon-γ Therapy for Cytokine Storm Syndromes (Fabrizio De Benedetti)....Pages 569-580
Alternative Therapies for Cytokine Storm Syndromes (Seza Ozen, Saliha Esenboga)....Pages 581-593
Salvage Therapy and Allogeneic Hematopoietic Cell Transplantation for the Severe Cytokine Storm Syndrome of Hemophagocytic Lymphohistiocytosis (Rebecca A. Marsh)....Pages 595-606
Back Matter ....Pages 607-617
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