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中枢神经系统转移-Central Nervous System Metastases

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上传于 2020-03-02 14次下载 1832次围观
文件编号:6265
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标题(title):Central Nervous System Metastases
中枢神经系统转移
作者(author):Manmeet Ahluwalia, Philippe Metellus, Riccardo Soffietti
出版社(publisher):Springer International Publishing
大小(size):12 MB (12265610 bytes)
格式(extension):pdf
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This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives.

Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach.

Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.




Table of contents :
Front Matter ....Pages i-xiii
Front Matter ....Pages 1-1
Epidemiology of Central Nervous System Metastases (Linda Dirven, Martin J. B. Taphoorn)....Pages 3-14
Pathology of Brain Metastasis (Dana A. Mustafa, Rute Pedrosa, Johan M. Kros)....Pages 15-29
Molecular Mechanisms in Brain Metastasis (Ekrem Emrah Er, Adrienne Boire)....Pages 31-41
Genomic Characterization of Brain Metastases: Implications for Precision Medicine (Franziska M. Ippen, Elisa Aquilanti, Helen D’Couto, Julia Grosch, Priscilla K. Brastianos)....Pages 43-58
Brain Metastases Cell Partners and Tumor Microenvironment (Pedro García-Gómez, Neibla Priego, Laura Álvaro-Espinosa, Manuel Valiente)....Pages 59-71
Liquid Biopsy Diagnosis of CNS Metastases (Mafalda Antunes Ferreira, Silvia D’Ambrosi, Thomas Würdinger, Pieter Wesseling, Danijela Koppers-Lalic)....Pages 73-86
Preclinical Models of Brain Metastases (Alex Wu, Anurag N. Paranjape, Brunilde Gril)....Pages 87-105
Front Matter ....Pages 107-107
Clinical Presentation of Brain Metastases (Annette Compter, Dieta Brandsma)....Pages 109-115
Epilepsy in CNS Metastases (Roberta Rudà, Alessia Pellerino, Riccardo Soffietti)....Pages 117-125
Safety, Tolerability, and Use of Steroids (Fabian Wolpert, Patrick Roth)....Pages 127-137
Anticoagulation in Patients with Brain Metastases (Christine Marosi, Cihan Ay)....Pages 139-143
Imaging of Brain Metastases: Diagnosis and Monitoring (Gabriel C. T. E. Garcia, Sophie Bockel, Michaël Majer, Samy Ammari, Marion Smits)....Pages 145-158
Metabolic Imaging of Brain Metastasis (Norbert Galldiks, Bogdana Suchorska, Nathalie L. Albert, Jörg C. Tonn)....Pages 159-171
Clinical, Imaging, and CSF Cytological Presentation of Leptomeningeal Metastases from Solid Non-CNS Primary Tumors (Emilie Le Rhun, Michael Weller)....Pages 173-179
Front Matter ....Pages 181-181
Surgery in Brain Metastasis Management: Therapeutic, Diagnostic, and Strategic Considerations (Philippe Metellus, Johan Pallud, Zvi Ram, Colin Watts, Manfred Westphal)....Pages 183-190
Surgical Resection for Brain Metastases (Ali S. Haider, Raymond Sawaya, Sherise D. Ferguson)....Pages 191-198
Stereotactic Radiosurgery for Brain Metastases (Christophe Marques, Eric L. Chang)....Pages 199-238
Whole Brain Radiotherapy (WBRT) for Brain Metastases (Frédéric Dhermain)....Pages 239-245
Combining Radiosurgery and Systemic Therapies for Treatment of Brain Metastases (Veronica Chiang, Stephanie Cheok)....Pages 247-258
Brain Metastases from Lung Tumors (Andrew Dhawan, Manmeet Ahluwalia)....Pages 259-266
Current Treatment Strategies in Breast Cancer Brain Metastases (Rupert Bartsch, Elisabeth Sophie Bergen, Karin Dieckmann, Anna Sophie Berghoff, Matthias Preusser)....Pages 267-279
Management of Melanoma Brain Metastasis (C. Boutros, C. Robert)....Pages 281-287
Miscellaneous Metastases (Andrew Dhawan, David Peereboom)....Pages 289-299
Treatment of Leptomeningeal Metastases (Emilie Le Rhun, Michael Weller)....Pages 301-311
Front Matter ....Pages 313-313
Neurocognitive Toxicity from Radiation Therapy for Brain Metastases (Karine A. Al Feghali, Caroline Chung, Jeffrey S. Wefel, Mariana E. Bradshaw)....Pages 315-328
Neurological Complications of Chemotherapy (Maria Diaz, David Schiff)....Pages 329-340
Neurological Complications of Targeted Therapies (Ugonma N. Chukwueke, Eudocia Q. Lee, Patrick Y. Wen)....Pages 341-363
Neurological Complications of Immune-Based Therapies (Ugonma N. Chukwueke, Eudocia Q. Lee, Patrick Y. Wen)....Pages 365-372
Health-Related Quality of Life Related to Toxicity Treatments in Central Nervous System Metastases (Tobias Walbert, Erika S. Horta)....Pages 373-382
Front Matter ....Pages 383-383
Prognostic Indices for Patients with Brain Metastases (Paul W. Sperduto)....Pages 385-396
Prevention Strategies for Brain Metastasis (Riccardo Soffietti, Alessia Pellerino, Roberta Rudà)....Pages 397-406
Clinical Trials: Endpoints and Outcome Assessment (Nancy U. Lin)....Pages 407-421
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