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信号量:新出现的生理和病理活动的多样性-Semaphorins: A Diversity of Emerging Physiological and Pathological Activities

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文件编号:5618
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标题(title):Semaphorins: A Diversity of Emerging Physiological and Pathological Activities
信号量:新出现的生理和病理活动的多样性
作者(author):Atsushi Kumanogoh (eds.)
出版社(publisher):Springer Japan
大小(size):6 MB (5828101 bytes)
格式(extension):pdf
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This book presents the current concepts of semaphorin biology. In the early 1990s, semaphorins were originally identified as axon guidance cues that function during neuronal development. However, cumulative findings have clarified that they have diverse functions in many physiological processes, including cardiogenesis, angiogenesis, vasculogenesis, osteoclastogenesis, retinal homeostasis, and immune regulation. Additionally, they have been implicated in the pathogenesis of various human diseases, including tumorigenesis/tumor metastasis, neuroregenerative diseases, retinal degeneration, irregular pulse/sudden death, and immune disorders. Based on this current research background, the book covers the essential state-of-the-art findings for basic scientists in biochemistry, molecular biology, neuroscience, developmental biology, and structural biology, as well as for physicians in neurology, cardiology, oncology, orthopedic surgery, otorhinolaryngology, ophthalmology, allergology, and rheumatology.


Table of contents :
Front Matter....Pages i-viii
Semaphorin Receptors and Their Signaling....Pages 1-17
Semaphorin Regulation of Neural Circuit Assembly in the Central Nervous System....Pages 19-37
Axon Guidance in the Spinal Cord....Pages 39-63
Semaphorins and Cell Migration in the Central Nervous System....Pages 65-85
Structure of Semaphorins and Their Receptors....Pages 87-106
Regulation of Angiogenesis and Tumor Progression by Semaphorins....Pages 107-135
Semaphorins in the Immune System....Pages 137-157
Semaphorins in Bone Homeostasis....Pages 159-173
Semaphorin in the Heart....Pages 175-187
Semaphorins and Neurodegenerative Disorders....Pages 189-205
Semaphorin in the Retinal System....Pages 207-221
Back Matter....Pages 223-226

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