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高尔基体和中心粒:功能、相互作用和在疾病中的作用-The Golgi Apparatus and Centriole: Functions, Interactions and Role in Dise文件编号:1203

上传于 2020年2月27日 10:23
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标题(title):The Golgi Apparatus and Centriole: Functions, Interactions and Role in Disease
作者(author):Malgorzata Kloc
出版社(publisher):Springer International Publishing
大小(size):12 MB (13051172 bytes)

This volume takes a closer look how the cell organelles Golgi apparatus (also known as the Golgi complex or Golgi body), and centriole are structurally and functionally intertwined.

Initially, it was believed that the role of Golgi complex is limited to the packaging and preparation for secretion of various cellular proteins, while the centriole participates in cell division and cilia formation. However, since their discovery nearly 200 years ago, it became clear that these two organelles are interacting, and that their functions are much more complex and far reaching than previously thought. Recent findings indicate that the Golgi–Centriole relationship may be important for directional protein transport, cell polarization and cell cycle progression. Current studies indicate that Golgi and centriole also participate in development and act as cellular and immunological sensors, and that their abnormalities lead to cell and developmental abnormalities, Alzheimer, cancer, various lipid disorders and neurological and immunological diseases in humans.

This volume combines the latest information on the structure, molecular composition, and roles of Golgi and centriole in various cellular functions and diseases. The better understanding of the Golgi–centriole interactions may lead to the development of novel therapies for the treatment of various diseases, including cancer.

Table of contents :
Front Matter ....Pages i-xix
Front Matter ....Pages 1-1
The Evolution of Centriole Structure: Heterochrony, Neoteny, and Hypermorphosis (Tomer Avidor-Reiss, Katerina Turner)....Pages 3-15
The Role of Protein Acetylation in Centrosome Biology (Delowar Hossain, William Y. Tsang)....Pages 17-25
Formins, Golgi, and the Centriole (John Copeland)....Pages 27-48
Role of Intracellular Transport in the Centriole-Dependent Formation of Golgi Ribbon (Alexander A. Mironov, Ivan D. Dimov, Galina V. Beznoussenko)....Pages 49-79
RhoA Pathway and Actin Regulation of the Golgi/Centriole Complex (Malgorzata Kloc, Ahmed Uosef, Jarek Wosik, Jacek Z. Kubiak, Rafik Mark Ghobrial)....Pages 81-93
Multiple Roles of Rab GTPases at the Golgi (Cinzia Progida)....Pages 95-123
Front Matter ....Pages 125-125
Positioning of the Centrosome and Golgi Complex (Amos Orlofsky)....Pages 127-200
Centriole Positioning: Not Just a Little Dot in the Cell (Angel-Carlos Roman, Sergio Garrido-Jimenez, Selene Diaz-Chamorro, Francisco Centeno, Jose Maria Carvajal-Gonzalez)....Pages 201-221
The MTOC/Golgi Complex at the T-Cell Immunological Synapse (Meritxell Roig-Martinez, Elena Saavedra-Lopez, Paola V. Casanova, George P. Cribaro, Carlos Barcia)....Pages 223-231
Semi-Intact Cell System for Reconstituting and Analyzing Cellular Golgi Dynamics (Fumi Kano, Masayuki Murata)....Pages 233-250
Front Matter ....Pages 251-251
The Centrosome as a Geometry Organizer (Marco Regolini)....Pages 253-276
Coordination of Embryogenesis by the Centrosome in Drosophila melanogaster (Caitlyn Blake-Hedges, Timothy L. Megraw)....Pages 277-321
Centrosomes in Branching Morphogenesis (Sofia J. Araújo)....Pages 323-336
MTOC Organization and Competition During Neuron Differentiation (Jason Y. Tann, Adrian W. Moore)....Pages 337-357
The Golgi Apparatus in Polarized Neuroepithelial Stem Cells and Their Progeny: Canonical and Noncanonical Features (Elena Taverna, Wieland B. Huttner)....Pages 359-375
Communication of the Cell Periphery with the Golgi Apparatus: A Hypothesis (Werner Jaross)....Pages 377-387
Front Matter ....Pages 389-389
Breaking Bad: Uncoupling of Modularity in Centriole Biogenesis and the Generation of Excess Centrioles in Cancer (Harold A. Fisk, Jennifer L. Thomas, Tan B. Nguyen)....Pages 391-411
Centrosome Amplification and Tumorigenesis: Cause or Effect? (Arunabha Bose, Sorab N. Dalal)....Pages 413-440
Golgi Structure and Function in Health, Stress, and Diseases (Jie Li, Erpan Ahat, Yanzhuang Wang)....Pages 441-485
Selected Golgi-Localized Proteins and Carcinogenesis: What Do We Know? (Piotr Donizy, Jakub Marczuk)....Pages 487-529

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