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默里和纳德尔的呼吸医学教科书-Murray & Nadel’s Textbook of Respiratory Medicine文件编号:555

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标题(title):Murray & Nadel’s Textbook of Respiratory Medicine
默里和纳德尔的呼吸医学教科书
作者(author):V. Courtney Broaddus, Robert J. Mason, Joel D. Ernst, Talmadge E. King Jr., Stephen C. Lazarus, John F. Murray, Jay A. Nadel, Arthur S. Slutsky, Michael B. Gotway
出版社(publisher):Elsevier
大小(size):537 MB (562807032 bytes)
格式(extension):pdf
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Cleaned hardcover version with correct pagination and bookmarks.
Table of contents :
Murray & Nadel’s Textbook of Respiratory Medicine......Page 2
Copyright page......Page 3
Dedication for Sixth Edition......Page 4
Contributors......Page 5
Preface to the Sixth Edition......Page 19
Preface to the First Edition......Page 20
Videos......Page 21
Gross and Subgross Organization......Page 26
Airways......Page 29
Pulmonary Circulation......Page 32
Terminal Respiratory Units......Page 35
Innervation......Page 39
The Pleural Space and Pleuras......Page 40
Comparison of the Lung of Mice and Humans......Page 42
Key Readings......Page 44
References......Page 45
Stages of Lung Development......Page 50
Tissue Interactions and Lung Development......Page 53
Retinoic Acid......Page 54
Wnts and β-Catenin......Page 55
NKX2-1......Page 56
Posttranscriptional Gene Regulation in Lung Development......Page 57
Key Readings......Page 59
References......Page 60
Introduction......Page 64
Genomic Maps......Page 65
Public Databases......Page 67
Association Studies......Page 68
Epigenetics......Page 69
Acute Respiratory Distress Syndrome......Page 72
Lung Cancer......Page 73
Fibrosing Idiopathic Interstitial Pneumonia......Page 74
Key Readings......Page 75
References......Page 76
Ventilation......Page 79
Functional Residual Capacity, Residual Volume, and Total Lung Capacity......Page 80
Alveolar Ventilation......Page 81
Physiologic Dead Space......Page 82
Nontopographic Inequality......Page 83
Pressure Inside Blood Vessels......Page 84
Pulmonary Vascular Resistance......Page 85
Pressure-Flow Relations......Page 86
Effect of Lung Volume......Page 87
Three-Zone Model for the Distribution of Blood Flow......Page 88
Other Factors Affecting the Distribution of Blood Flow......Page 89
Hypoxic Pulmonary Vasoconstriction......Page 90
Nonrespiratory Functions of the Pulmonary Circulation......Page 92
Oxygen......Page 93
Carbon Dioxide......Page 94
Gas Exchange......Page 95
Hypoventilation......Page 96
Oxygen Uptake along the Pulmonary Capillary......Page 98
Diffusing Capacity......Page 99
Shunt......Page 101
Gas Exchange in a Single Lung Unit......Page 102
Pattern in the Normal Lung......Page 103
Traditional Assessment of Ventilation-Perfusion Inequality......Page 104
Distributions of Ventilation-Perfusion Ratios......Page 105
Multiple Inert Gas Elimination Technique.......Page 106
Distributions in Lung Disease.......Page 107
Ventilation-Perfusion Inequality and Carbon Dioxide Retention......Page 108
Oxygen Sensing......Page 109
Key Readings......Page 110
References......Page 111
Volume......Page 114
The Combined Gas Law......Page 115
Elastic Recoil of the Lungs......Page 116
Hysteresis and Stress Adaptation......Page 117
Respiratory Muscles see Chapter 97......Page 118
Fatigue of Respiratory Muscles......Page 119
Integration of Lung and Chest Wall Mechanics......Page 120
The Impact of Positive End-Expiratory Pressure on Pleural Pressure......Page 121
Laminar versus Turbulent Flow......Page 122
Flow Limitation......Page 124
The Bernoulli Effect and Wave Speed Theory.......Page 125
Intrinsic PEEP during Positive-Pressure Ventilation of COPD......Page 126
Measurement of Static Compliance and Resistance during Mechanical Ventilation......Page 127
Measuring Work of Breathing in a Spontaneously Breathing Patient......Page 128
Key Readings......Page 129
eFigure Image Gallery......Page 130
References......Page 132
Pulmonary Vascular Pressures......Page 134
General Design......Page 135
Blood-Gas Interface......Page 136
Imaging the Pulmonary Circulation......Page 137
Pulmonary Vascular Resistance......Page 138
Lung Volume.......Page 139
Pulmonary Vascular Pressure-Volume Curve......Page 140
Mechanical Stress and the Lung Circulation......Page 141
Cyclic Stretch......Page 142
Response Elements......Page 143
Transcapillary Exchange and the Fluid Flux Equation......Page 145
Capillary Endothelium......Page 146
Alveolar Epithelium......Page 147
Interstitial Compliance......Page 148
Pulmonary Capillary Pressure and Plasma Osmotic Pressure in Edema Formation......Page 149
Regional Differences in Endothelial Permeability......Page 150
Cytoskeletal Alterations......Page 151
Endothelial Water Permeability and Albumin Transcytosis......Page 152
Strategies to Reverse Permeability and Restore Barrier Integrity......Page 153
Key Readings......Page 154
eFigure Image Gallery......Page 155
References......Page 158
Conjugate Acids and Bases......Page 166
Measurements......Page 167
Bicarbonate......Page 168
Base Excess......Page 169
Role of the Kidneys......Page 170
Nomenclature of Acid-Base Disorders......Page 171
Anion Gap Concept......Page 173
Lactic Acidosis......Page 175
Diabetic Ketoacidosis......Page 177
Type 1 Renal Tubular Acidosis.......Page 179
Type 2 Renal Tubular Acidosis.......Page 180
Urine Net Charge and Osmolar Gap......Page 181
Therapy......Page 182
Mechanical Ventilation......Page 183
Therapy......Page 184
Clinical Manifestations......Page 185
Causes......Page 186
Key Readings......Page 187
References......Page 189
Introduction......Page 191
Alveolar Type I Cells......Page 192
Alveolar Type II Cells......Page 195
Physiologic Functions of Pulmonary Surfactant......Page 197
Composition and Pool Sizes......Page 198
Surfactant Protein A......Page 199
Surfactant Protein B......Page 200
Surfactant Protein D......Page 201
Secretion and Extracellular Processing of Surfactant......Page 202
Primary Surfactant Deficiency of the Newborn......Page 203
Interstitial Lung Diseases......Page 204
Key Readings......Page 205
References......Page 207
Evidence for Active Fluid Transport in the Intact Lung......Page 212
Ion Transport in Alveolar and Distal Airway Epithelial Cells......Page 213
Regulation of Lung Epithelial Fluid Transport......Page 215
Mechanisms That Can Impair the Resolution of Alveolar Edema......Page 216
Alveolar Fluid Transport Under Pathologic Conditions......Page 217
Key Readings......Page 218
References......Page 219
Normal Airway Mucins......Page 221
Manifestations of Mucous Hypersecretion Depend on Airway Location......Page 222
Importance of Mucous Hypersecretion in Chronic Inflammatory Airway Diseases......Page 223
Cystic Fibrosis see Chapter 47......Page 224
Asthma see Chapters 41 and 42......Page 225
Chronic Bronchitis and COPD see Chapters 43 and 44......Page 226
Roles of Reactive Oxygen Species in Airway Epithelial Mucin Production......Page 227
Toll-like Receptors......Page 228
GPCR Can Exaggerate EGFR-Dependent Mucin Production......Page 229
Mucus Biology: Present Status and Future Opportunities......Page 230
Key Readings......Page 231
References......Page 232
Definition and Description of an Aerosol......Page 235
Evaluation of Aerosol Particle Size......Page 236
Pressurized Metered-Dose Inhalers......Page 237
The Inhaled Mass......Page 238
Deposition......Page 239
Control of Breathing Pattern and Aerosol Deposition......Page 240
Asthma......Page 241
Delivery of Inhaled Medications to Young Children......Page 243
Aerosol Delivery during Mechanical Ventilation......Page 245
Mucociliary Clearance and Disease......Page 246
Toxins......Page 247
Infectious Aerosols......Page 248
Key Readings......Page 250
References......Page 251
Overview of the Components of Lung Innate Immunity......Page 253
Pentraxins and Other Secreted Pattern Recognition Receptors......Page 256
C-Type Lectin Receptors.......Page 258
Summary......Page 260
Epithelium......Page 261
Polymorphonuclear Leukocytes......Page 262
Mononuclear Phagocytes......Page 264
Functions of Resident and Interstitial Alveolar Macrophages.......Page 266
Functions of Recruited Monocytes and Macrophages.......Page 267
Mouse and Human Lung Dendritic Cell Subsets.......Page 270
Functions of Lung Dendritic Cells.......Page 272
System Integration......Page 273
Key Readings......Page 274
References......Page 275
Components of the Immune System: Overview......Page 282
Structure of Immunoglobulin and the B-Cell Receptor for Antigen......Page 284
Formation of the B-Cell Receptor Repertoire......Page 285
Isotype Switching and Function of the Different Immunoglobulin Classes......Page 286
B-Cell Development......Page 287
T-Cell Receptor Structure and T-Cell Receptor Repertoire Formation......Page 288
Antigen-Presenting Cells and the Major Histocompatibility Complex......Page 289
Presentation and T-Cell Recognition of Antigens......Page 290
T-Cell Tolerance: Prevention of Self-Reactivity......Page 291
T-Cell Activation and Co-Stimulation......Page 292
Subsets of T Helper Cells......Page 293
CD4+ T-Cell?B-Cell Collaboration and Regulation of Antibody Production......Page 294
Lymphocyte Populations and Trafficking in the Lung......Page 295
Immune Response to Autoantigens......Page 297
Granulomatous Lung Disease......Page 298
Key Readings......Page 299
eFigure Image Gallery......Page 300
References......Page 304
Lung Cancer......Page 307
Invasive Adenocarcinoma.......Page 309
Adenocarcinoma Variants.......Page 310
TNM Staging: Potential Changes According to New Classification......Page 311
EGFR Mutation Testing......Page 313
Use of Minimal Stains to Maximize Tissue for Molecular Testing......Page 314
Small Cell Carcinoma......Page 315
Combined SCLC.......Page 316
Typical and Atypical Carcinoid......Page 317
Large Cell Carcinoma......Page 318
Solitary Fibrous Tumor......Page 319
Idiopathic Interstitial Pneumonias......Page 320
Usual Interstitial Pneumonia/Idiopathic Pulmonary Fibrosis.......Page 321
Nonspecific Interstitial Pneumonia.......Page 323
Organizing Pneumonia/Cryptogenic Organizing Pneumonia.......Page 324
Diffuse Alveolar Dam
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